Home > Lung Facts >
Lung Facts will be updated regularly. The concept builds on two previous publications of the European Lung White Book. This drew on data from the World Health Organization (WHO) and European Centre for Disease Prevention and Control. A key limitation of this previous publication was the variance in data resources available as well as data collection, which prevented an accurate comparison of the state of lung health between countries.
Lung Facts aims to go one step further by providing a systematic, uniform approach. By taking data from the GBD studies, Lung Facts is able to present a more uniform evaluation of the current state of lung health for seven respiratory disease areas.
What is the Global Burden of Disease (GBD) study?
The Global Burden of Disease study (GBD) brings together administrative data, and data from registration systems, disease registries, epidemiological surveillance systems and primary scientific studies, alongside survey data on self-reported health and health-related risk behaviours. This data is collected at regional, national and sub-national levels from across the globe and integrated into a single statistical model.
In using a single cohesive approach across the world, the GBD study brings together a huge volume of data and evidence in order to estimate disease-specific incidence, prevalence and mortality alongside a demographic model that allows the calculation of Years of Life Lost and Disability-Adjusted Life Years.
To combat issues with underdiagnosis, the GBD corrects for the underreporting of data. For example, if a country has very different rates of a health condition than similar neighbours, the model will assume there is some degree of reporting error, unless there is some other factor that can reasonably explain the discrepancy (e.g. much higher rates of smoking).
Lung Facts presents the incidence, prevalence, mortality, disability-adjusted life years (DALYs), years of life lost (YLL) and cost to society (in the form of monetised DALYs) in chart format to build up a picture and usable reference for the burden of lung disease.
Lung Facts currently provides data on countries in the WHO European Region. This includes 53 countries: Albania, Andorra, Armenia, Austria, Azerbaijan, Belarus, Belgium, Bosnia and Herzegovina, Bulgaria, Croatia, Cyprus, Czech Republic, Denmark, Estonia, Finland, France, Georgia, Germany, Greece, Hungary, Iceland, Ireland, Israel, Italy, Kazakhstan, Kyrgyzstan, Latvia, Lithuania, Luxembourg, Malta, Moldova, Monaco, Montenegro, Netherlands, North Macedonia, Norway, Poland, Portugal, Romania, Russia, San Marino, Serbia, Slovakia, Slovenia, Spain, Sweden, Switzerland, Tajikistan, Turkey, Turkmenistan, Ukraine, United Kingdom, Uzbekistan.
Health metrics in the GBD
Incidence looks at how common a disease is within a population. It measures the number of new cases per year as a number and as a rate per head of the population. These figures can be used to understand the probability of a person developing a specific condition within the population.
Prevalence is a measurement showing the share of the population that has a given condition. It includes all new and pre-existing cases within the time period and is reported in Lung Facts as total numbers and as rates.
Mortality presents the number of deaths from a particular condition. Total number of deaths and death rate is used in Lung Facts.
Disability-adjusted life years (DALYs)
One DALY refers to a year of healthy life lost to sickness (disability). DALYs allow us to estimate the total number of healthy years lost due to specific conditions. If one DALY is prevented, it means that we have saved one year or a productive health life.
Years of life lost (YLL)
YLL is a measure of premature death that takes into account both the rate of deaths (mortality) and the age at which it occurs. For example, if only mortality measurements are used, deaths at the age of 90 would be treated the same as a death at the age of 30. YLLs are calculated by looking at the total number of deaths multiplied by a global standard life expectancy at the age at which death occurs.
Cost to society: monetised DALYs
Lung Facts has used the available data from GBD to generate a new figure showing monetised DALYs. When 1 DALY is valued at the GDP per capita for a specific country in international dollars (Int$2019) based on purchasing power parity (PPP), it represents the societal monetary cost of a disease for comparison between countries. Purchasing power parity (PPP) is a theory which states that exchange rates between currencies are in equilibrium when their purchasing power is the same. As such, PPP-adjusted figures represented by international dollars (Int$) allows for a better comparison between countries.
If policy makers were willing to adopt this valuation of a DALY, it can also be used as a suggested upper limit of investment to inform negotiations for what would be a potentially cost-effective amount of money needed to tackle the burden in each country.
The figure is generated by using the Gross Domestic Product (GDP) per capita ̶ a country’s economic output per person, which is regarded as a marker of wealth for a specific country. GDP per capita is used as this is the lower recommended cost-effectiveness threshold suggested by the WHO’s ‘Choosing Interventions That Are Cost Effective (WHO-CHOICE)’ initiative. This initiative suggests that 1 to 3*GDP per capita per DALY prevented could act as a country-specific cost-effectiveness threshold when there is no other recommended threshold.
The Lung Facts cost to society (i.e. monetised DALY) figures are calculated as follows: DALY x GDP per capita (Int$2019).
This figure has not previously been available and now provides an economic basis to advocate for change.
How can this figure be used?
- As a potentially cost-effective upper limit on investment – anything spent up to this amount could be a considered cost-effective investment in terms of preventing DALYs if policy makers were willing to accept the monetary value of 1 DALY as equal to the GDP per capita of their country.
- To understand how much budget to allocate for a X% reduction in DALYs – for a 1% reduction you could use the calculation: GDP per capita*0.01*DALYs
- To understand how many DALYs should be prevented for a pre-specified allocated budget – for an example $5m budget you would use the calculation: 5,000,000/GDP per capita.
Charts presented in Lung Facts:
- Monetised DALYS – societal cost for whole population in international dollars
This chart gives a financial value to the number of healthy years lost in disability-adjusted life years (DALYs) to each given disease. When 1 DALY is valued at the GDP per capita for a specific country in international dollars (Int$2019) based on purchasing power parity (PPP), it represents the societal monetary cost of each given disease for comparison between countries. If policy makers were willing to adopt this valuation of a DALY, it can also be used as a suggested upper limit of investment to inform negotiations for what could be a potentially cost-effective amount of money needed to tackle the burden in each country.
- Monetised DALYS – societal cost per 100,000 people in international dollars
This chart follows the same principle as the above description but uses the DALY rate per 100,000 people instead of the mean DALYs for the whole population.
A report, entitled ‘How much should be invested in lung care across Europe? Applying a monetary value to Disability-Adjusted Life Years within the International Respiratory Coalition’s Lung Facts’, provides context, background and empirical evidence to support the use of this figure in Lung Facts as a framework to enable informed discussions with policy and decision-makers and to guide financial investment in alleviating the burden of lung conditions. This report is currently in publication. A link will be provided once published.
Non-GBD disease areas
Several respiratory conditions were not included within the GBD database or published literature. Or at least not in a way that we could extract data for a specific condition. Therefore, a systematic approach was taken to collect data for influenza, alpha-1-antitrypsin deficiency, bronchiectasis, cystic fibrosis, obstructive sleep apnoea and pulmonary vascular disease.
For influenza, incidence and mortality data were taken from the GBD 2017 Influenza Collaborators paper*, which was identified through systematic searches for GBD studies conducted in January 2022.
*Collaborators GBDI. Mortality, morbidity, and hospitalisations due to influenza lower respiratory tract infections, 2017: an analysis for the Global Burden of Disease Study 2017. Lancet Respiratory Medicine 2019 ;7: 69-89.
Focused searches of bibliographic databases were used to find studies on alpha-1, bronchiectasis, cystic fibrosis, obstructive sleep apnoea and pulmonary vascular disease. Experts in the field were also consulted to identify any unpublished or registry data.
These conditions were split into two categories: commonly studied conditions (cystic fibrosis, obstructive sleep apnoea) and less-commonly studied conditions (alpha-1, bronchiectasis, pulmonary hypertension).
Searches for the commonly studied conditions sought to identify reviews and systematic reviews only. For the less-commonly studied conditions, all study designs were sought since it was anticipated that there would be a limited amount of literature available.
All searches took place on 26 May 2022, and covered the period between 1 January 2010 and 26 May 2022, to be consistent with the 2010 limit of searches for the GBD diseases.
Lung Facts Steering group
The Lung Facts Steering group is responsible for overseeing all decision about the Lung Facts:
- Tobias Welte – Chair, Professor of Pulmonary Medicine and Director of the Department of Pulmonary and Infectious Diseases at Hannover University School of Medicine, Hannover, Germany
- Guy Joos, Emeritus Professor at Ghent University and Pulmonologist, Ghent University Hospital
- Zorana Jovanovic Andersen, Professor in Environmental Epidemiology at the Department of Public Health, University of Copenhagen, Denmark
- Charlotte Ulrik Suppli, Professor of Respiratory Medicine at the University of Copenhagen
Lung Facts Advisory Group
The Lung Facts Advisory group provided advice and support on the visualisation of the data into the Lung Fact website:
- Helena Backman, Associate Professor of Epidemiology and Public Health, at the OLIN-studies, Norrbotten County Council, and Department of Public Health and Clinical Medicine, Umeå University, Sweden.
- Robab Breyer-Kohansal, Associate Professor for Pulmonary Medicine at the Ludwig Boltzmann Institute for Lung Health and Head of the Department of Respiratory and Pulmonary Diseases, Clinic Hietzing, Vienna Austria
- Lies Lahousse, Ghent University Belgium, Associate Professor of Pharmacoepidemiology at Ghent University, Belgium
- Lowie Vanfleteren, Associate Professor of Pulmonary Medicine at the University of Gothenburg and Pulmonologist at Sahlgrenska University Hospital.
- Stefan Karrasch, Physician and Scientist at LMU University Hospital, Munich, Germany
- James Allinson, Consultant Respiratory Physician at the Royal Brompton Hospital, London, UK and Honorary Senior Clinical Lecturer at the National Heart and Lung Institute, Imperial College London, UK.
All data was collected and the economics calculated by a team from the School of Health and Related Research (ScHARR), University of Sheffield, UK:
- Sue Harnan, Senior Research Fellow
- Chris Carroll, Reader in Systematic Review and Evidence Synthesis
- Colin Angus, Senior Research Fellow
- Matthew Franklin, Senior Health Economist
- Emma Simpson, Senior Research Fellow
- Anthea Sutton, Senior Information Specialist
For more information on how this data has been visualised, please contact Pippa Powell and Lauren Anderson at the European Lung Foundation.